Microsystems for Personalised Medicine
Bee Luan KHOO
Publications
2024
73. Ma, Z., Jia, W., Zhang, J., He, X., Liu, S., Hilal, M. E., Zhou, X., Yang, Z., Chen, Z., Shi, P., & Khoo, B. L. (2024). Integrated Piezoelectric Vascular Graft for continuous real‐time hemodynamics monitoring. Advanced Functional Materials, 34(48). https://doi.org/10.1002/adfm.202409874. [Link]
72. YS Liu, C Zhang, BL Khoo, P Hao, SL Chua. (2024) Dual-species proteomics and targeted intervention of animal-pathogen interactions. Journal of Advanced Research. [Link]
71. Liao, J., Ma, Z., Liu, S., Li, W., Yang, X., Hilal, M. E., Zhou, X., Yang, Z., & Khoo, B. L. (2024). Programmable microfluidic‐assisted highly conductive hydrogel patches for customizable soft electronics. Advanced Functional Materials.[Link] *in-print* (July 2024)
70. Ma Z, Khoo BL. (2024) Recent advances in laser-induced-graphene-based soft skin electronics for intelligent healthcare. Soft Science.[Link]
69. W Lin, L Ai, Y Wang, X Yang, J Liao, Q Pan, Y Hong, S Liu, Z Long. (2024) Imperceptible liquid metal based tattoo for Human-Machine interface on hairy skin. Chemical Engineering Journal 490, 151595. [Link]
68. Bangul Khan et al., and Bee Luan Khoo, (2024) Advancements in wearable sensors for cardiovascular disease detection for health monitoring, Materials Science and Engineering: R: Reports.[Link]
67. Haojun Hua et al., and Bee Luan Khoo, (2024) AIEgen-deep: Deep learning of single AIEgen-imaging pattern for cancer cell discrimination and preclinical diagnosis, Biosensors and Bioelectronics, [Link]
66. B Zhang, J Li, J Zhou, L Chow, G Zhao, Y Huang, Z Ma, Q Zhang, Y Yang, ...A three-dimensional liquid diode for soft, integrated permeable electronics. Nature 628 (8006), 84-92.
65. Wang Guo et al. and Bee Luan Khoo (2024), Thin and soft Ti3C2Tx MXene sponge structure for highly sensitive pressure sensor assisted by deep learning, Chemical Engineering Journal.[Link]
64. Y Ma, WS Tang, SY Liu, BL Khoo, SL Chua. (2024) Juglone as a Natural Quorum Sensing Inhibitor against Pseudomonas aeruginosa pqs-Mediated Virulence and Biofilms. ACS Pharmacology & Translational Science 7 (2), 533-543. [Link]
63. H Hua, Y Zhou, W Li, J Zhang, Y Deng, BL Khoo (2024) Microfluidics-based patient-derived disease detection tool for deep learning-assisted precision medicine. Biomicrofluidics 18 (1).
62. S Wang, SY Chan, Y Deng, BL Khoo, SL Chua. (2024) Oxidative stress induced by Etoposide anti-cancer chemotherapy drives the emergence of tumor-associated bacteria resistance to fluoroquinolones. Journal of Advanced Research 55, 33-44. [Link]
61. YWS Yeung, Y Ma, Y Deng, BL Khoo, SL Chua. (2024) Bacterial Iron Siderophore Drives Tumor Survival and Ferroptosis Resistance in a Biofilm‐Tumor Spheroid Coculture Model. Advanced Science, 2404467[Link]
2023
60. Hua, H. et al, and Bee Luan Khoo A deformability-based biochip for precise label-free stratification of metastatic subtypes using deep learning. Microsyst Nanoeng 9, 120 (2023).[Link]
59. Liu, S., Liao, J., Huang, X., Zhang, Z., Wang, W., Wang, X., Shan, Y., Li, P., Hong, Y., Peng, Z., et al. (2023). Green Fabrication of Freestanding Piezoceramic Films for Energy Harvesting and Virus Detection. Nanomicro Lett 15, 131. [Link]
58. Zhang, J., Li, W., Huang, Q., Fu, Y., Liu, Y., Luo, X., Zou, S., Chua, S.L., Leung, S., and Khoo, B.L. (2023). Label-free biosensor for non-invasive and low-cost detection of metastatic risk through urine biopsy. Sensors and Actuators B: Chemical 395, 134485. [Link]
57. Fu, Y., Deng, Y., Zhang, J., Chua, S.L., and Khoo, B.L. (2023). Biofilms exacerbate atherogenesis through macrophage-induced inflammatory responses in a fibrous plaque microsystem model. Acta Biomater. [Link]
56. Li, W., Zhou, Z., Zhou, X., Khoo, B.L., Gunawan, R., Chin, Y.R., Zhang, L., Yi, C., Guan, X., and Yang, M. (2023). 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-Chip. Adv Healthc Mater 12, e2202609.
55. Can Liquid Biopsy Cancer Research Offering Personalized Cancer Treatment in Gynecology be a Realistic Expectation? F Wong, BL Khoo, KKL Chan Clinical and Experimental Obstetrics & Gynecology 50 (6), 132
54. Ma, Y., Deng, Y., Hua, H., Khoo, B.L., and Chua, S.L. (2023). Distinct bacterial population dynamics and disease dissemination after biofilm dispersal and disassembly. ISME J 17, 1290-1302. [Link]
53. Khoo, B.L. (2023). Early detection of metastasis in ascites and peritoneal lavage - new perspectives using label-free microfluidic approaches. EBioMedicine 91, 104554.
52. Li, W., Zhou, Z., Zhou, X., Khoo, B.L., Gunawan, R., Chin, Y.R., Zhang, L., Yi, C., Guan, X., and Yang, M. (2023). 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-Chip. Adv Healthc Mater 12, e2202609.
51. Wang, S., Chan, S.Y., Deng, Y., Khoo, B.L., and Chua, S.L. (2023). Oxidative stress induced by Etoposide anti-cancer chemotherapy drives the emergence of tumor-associated bacteria resistance to fluoroquinolones. J Adv Res. [Link]
50. Zou, S., and Khoo, B.L. (2023). Subtyping based on immune cell fractions reveal heterogeneity of cardiac fibrosis in end-stage heart failure. Front Immunol 14, 1053793. [Link]
49. Deng, Y., Fu, Y., Chua, S.L., and Khoo, B.L. (2023). Biofilm Potentiates Cancer-Promoting Effects of Tumor-Associated Macrophages in a 3D Multi-Faceted Tumor Model. Small 19, e2205904. [Link]
2022
48. J.C. Liao, S.J. Zou, Y.L. Deng, Y. Jiang, S.L. Chua, B.L. Khoo, Multivariate analysis of liquid biopsies for real-time detection of patients with biofilm-associated infections (BAI), Chemical Engineering Journal 453 (2023) 139595. [Link]
47. TF Zhang, YL Deng, SL Yang, SL Chua, BZ Tang, BL Khoo, Bacterial Targeted AIE Photosensitizers Synergistically Promote Chemotherapy for the Treatment of Inflammatory Cancer, Chemical Engineering Journal [Link]
46. YT Fu, SJ Zou, BL Khoo, Label-free enrichment of blast cells from whole blood for leukemia monitoring, STAR Protocols, Cell Press [Link]
45. Xu J, Tang Q, Zhang R, Chen H, Khoo BL, Zhang X, et al. Sensitive detection of microRNAs using polyadenine-mediated fluorescence spherical nucleic acids and a microfluidic electrokinetic signal amplification chip. Journal of Pharmaceutical Analysis. 2022.
44. H. Jia et al., "A Quadrotor With a Passively Reconfigurable Airframe for Hybrid Terrestrial Locomotion," in IEEE/ASME Transactions on Mechatronics, doi: 10.1109/TMECH.2022.3164929.
43. Y.S. Liu, Y. Deng, C.K. Chen, B.L. Khoo#, S.L. Chua#, Rapid detection of microorganisms in a fish infection microfluidics platform, J Hazard Mater 431 (2022) 128572. [Link]
42. W. Li, Y. Zhou, Y. Deng, B.L. Khoo, Early Predictor Tool of Disease Using Label-Free Liquid Biopsy-Based Platforms for Patient-Centric Healthcare, Cancers (Basel) 14(3) (2022). [Link]
41. S. Zou, B.L. Khoo, A 6-gene panel as a signature to predict recovery from advanced heart failure using transcriptomic analysis, Genes & Diseases (2022). [Link]
40. Chen, C.K., Zhang, J., Bhingarde, A., Matotek, T., Barrett, J., Hardesty, B.D., Banaszak Holl, M.M., B.L. Khoo, 2022. A portable purification system for the rapid removal of microplastics from environmental samples. Chemical Engineering Journal 428, 132614. [Link]
2021
39. Hong, Y., Jin, L., Wang, B., Liao, J., He, B., Yang, T., Long, Z., Li, P., Zhang, Z., Liu, S., Lee, Y., Khoo, B.L., Yang, Z., 2021. A wood-templated unidirectional piezoceramic composite for transmuscular ultrasonic wireless power transfer. Energy & Environmental Science 14(12), 6574-6585. [Link]
38. Liao, J., Ren, J., Wei, H., Lam, R.H.W., Chua, S.L., B.L. Khoo, 2021. Label-free biosensor of phagocytosis for diagnosing bacterial infections. Biosensors and Bioelectronics 191, 113412. [Link]
37. Y. Deng, L. Yang, S.L. Chua, B.L. Khoo, The effects of biofilms on tumor progression in a 3D cancer-biofilm microfluidic model, Biosensors and Bioelectronics, 2021, 113113, ISSN 0956-5663, https://doi.org/10.1016/j.bios.2021.113113. [Link]
36. Zhang, J.; Chua, S.L.; B.L. Khoo Worm-Based Microfluidic Biosensor for Real-Time Assessment of the Metastatic Status. Cancers 2021, 13, 873. https://doi.org/10.3390/cancers13040873 [Link]
35. Shang M, ...B.L. Khoo, Lim CT. Microfluidic studies of hydrostatic pressure-enhanced doxorubicin resistance in human breast cancer cells, Lab on a Chip, 2021, DOI: 10.1039/D0LC01103G [Link]
34. Shang M, Kwon T, Hamel JP, Lim CT, B.L. Khoo, Han J. Investigating the influence of physiologically relevant hydrostatic pressure on CHO cell batch culture. Sci Rep. 2021;11(1):162. [Link]
FU, Y.; KHOO, B. Heterogeneity of biomarker expression in clinical urine biopsies, in Proceedings of the 1st International Electronic Conference on Cancers: Exploiting Cancer Vulnerability by Targeting the DNA Damage Response, 1–14 February 2021, MDPI: Basel, Switzerland,[Link]
2020
2019
28. B.L. Khoo et al. Nature Publishing Group Precision Oncology 2019, 3(1), 1-12; [Link]
27. B. L. Khoo, C. Bouquerel et al. Cancers 2019, 11(9), 1274; [Link]
26. B. L. Khoo et al. British journal of cancer 120 (4), 407 [Link]
25. Shang et al. Lab on a Chip 19 (3), 369-386 [Link]
24. B.L. Khoo et al. Cell Culture (Patent)
33. C. Chen, B.L. Khoo, A density-based threshold model for evaluating the separation of particles in heterogeneous mixtures with curvilinear microfluidic channels, Sci Reports (2020) 10, 18984 [Link]
32. Y. Fu, Y. Zhang, B.L. Khoo, Liquid biopsy technologies for hematological diseases, Medicinal Research Reviews (2020). [Link]
31. C. Chen, J. Liao, M. LI, B.L. Khoo, Urine biopsy technologies: Cancer and beyond, Theranostics 10(17) (2020) 7872-7888. [Link]
30. Zhang, J., Deng, Y. & Khoo, B.L., Fasting to enhance Cancer treatment in models: the next steps J Biomed Sci 27, 58 (2020). [Link]
29. B.L. Khoo et al. Leukemia detection (Patent)
2018
23. P. Durai et al. BJU International [Link]
22. B.L. Khoo et ak. Leukemia (Patent)
21. A. K. P. Tay, B. L. Khoo and M. E. Warkiani, Springer, Cham, 2018, pp. 57-75. [Link]
20. B. L. Khoo, G. Grenci, Y. B. Lim, S. C. Lee, J. Han and C. T. Lim, Nat Protoc, 2018, 13, 34-58. [Link]
19. Y. Zhou, D. Yang, Y. Zhou, B. L. Khoo, J. Han and Y. Ai, Anal Chem, 2018, 90, 912-919. [Link]
2017
18. C. Tzouanas, J. S. Y. Lim, Y. Wen, J. P. Thiery and B. L. Khoo, Chemosensors, 2017, 5, 30. [Link]
17. N. Kumar, A. S. Zaw, S. B. Kantharajanna, B. L. Khoo, C. T. Lim and J. P. Thiery, Transfus Med, 2017, 27 Suppl 5, 327-334. [Link]
16. D. J. Collins, B. L. Khoo, Z. Ma, A. Winkler, R. Weser, H. Schmidt, J. Han and Y. Ai, Lab Chip, 2017, 17, 1769-1777. [Link]
15. B. L. Khoo, P. K. Chaudhuri, C. T. Lim and M. E. Warkiani, in Ex Vivo Engineering of the Tumor Microenvironment, Springer, 2017. [Link]
2015
10. J. Nam, J. K. Tan, B. L. Khoo, B. Namgung, H. L. Leo, C. T. Lim and S. Kim, Biomicrofluidics, 2015, 9, 064117. [Link]
9. B. L. Khoo, S. C. Lee, P. Kumar, T. Z. Tan, M. E. Warkiani, S. G. Ow, S. Nandi, C. T. Lim and J. P. Thiery, Oncotarget, 2015, 6, 15578-15593. [Link]
8. M. E. Warkiani, A. K. Tay, B. L. Khoo, X. Xiaofeng, J. Han and C. T. Lim, Lab Chip, 2015, 15, 1101-1109. [Link]
2016
14. N. Kumar, A. S. Zaw, B. L. Khoo, S. Nandi, Z. Lai, G. Singh, C. T. Lim and J. P. Thiery, European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2016, 25, 4008-4015. [Link]
13. B. L. Khoo, P. K. Chaudhuri, N. Ramalingam, D. S. Tan, C. T. Lim and M. E. Warkiani, International journal of cancer. Journal international du cancer, 2016, 139, 243-255. [Link]
12. B. L. Khoo, G. Grenci, T. Jing, Y. B. Lim, S. C. Lee, J. P. Thiery, J. Han and C. T. Lim, Science Advances, 2016, 2, e1600274. [Link]
11. B. L. Khoo, P. Kumar, C. Lim and J. Thiery, in Circulating Tumor Cells, Springer, 2016. [Link]
5. M. E. Warkiani*, B. L. Khoo*, L. Wu, A. K. Tay, A. A. Bhagat, J. Han and C. T. Lim, Nature protocols, 2016, 11, 134-148. [Link]
2014
. B. L. Khoo, M. E. Warkiani, D. S. Tan, A. A. Bhagat, D. Irwin, D. P. Lau, A. S. Lim, K. H. Lim, S. S. Krisna, W. T. Lim, Y. S. Yap, S. C. Lee, R. A. Soo, J. Han and C. T. Lim, PLoS One, 2014, 9, e99409. [Link]
6. A. Wong, S. Tan, I. Soh, C. Tan, Y. Lim, A. Pang, J. Ho, S. Ow, R. Sundar, M. Pang, C. Chan, S. Buhari, M. Hartman, P. Iau, A. Tang, N. Wong, Y. S. Yap, B. L. Khoo, J. P. Thiery and S. C. Lee, Journal of Clinical Oncology, 2014, 32. [Link]
5. M. E. Warkiani*, B. L. Khoo*, D. S. Tan, A. A. Bhagat, W. T. Lim, Y. S. Yap, S. C. Lee, R. A. Soo, J. Han and C. T. Lim, The Analyst, 2014, 139, 3245-3255. [Link]
4. B. L. Khoo, M. Warkiani, G. Guan, D. Tan, A. Lim, W. Lim, Y. S. Yap, S. C. Lee, R. A. Soo, J. Han and C. T. Lim, presented in part at the The 15th International Conference on Biomedical Engineering, 2014. [Link]
3. M. E. Warkiani*, G. Guan*, B. L. Khoo*, W. C. Lee, A. A. S. Bhagat, P. K. Chaudhuri, D. S.-W. Tan, W. T. Lim, S. C. Lee and P. C. Chen, Lab on a Chip, 2014, 14, 128-137. [Link]