This study introduces a novel microfluidic model, TAMPIEB, designed to investigate the interactions between tumor-associated macrophages (TAMs) and cancer cells within the tumor microenvironment (TME), particularly focusing on the effects of bacterial distribution on immunomodulation. The research reveals that biofilm-induced inflammatory conditions can drive TAMs to transition from a pro-inflammatory M1-like state to an anti-inflammatory M2-like state, thereby promoting cancer progression. Key findings include the identification of mechanisms by which biofilms contribute to cancer hallmarks, such as reduced apoptosis susceptibility, increased cell viability, and enhanced epithelial-mesenchymal transition and metastasis. Additionally, biofilms formed by extratumoral bacteria may protect tumors from immune attacks by TAMs, a phenomenon that was visualized using various imaging techniques. The insights gained from this study highlight the potential of integrating anti-biofilm therapies with immunotherapy in clinical settings to combat tumor progression.
For more info, DOI: https://doi.org/10.1002/smll.202205904
Comments